Sumit Nagal progressed to the pre-quarterfinals after a hard-fought win over local favourite Renzo Olivo.
Gael Monfils thrilled the Roland Garros crowd with his 12th five-set victory at the French Open on Tuesday before revealing that he does not enjoy having to dig himself out of deep holes at Grand Slams.
Nadal is bidding for his second title in his 15th appearance at Melbourne Park
Ash Barty's bid to end the host nation's long wait for a homegrown Australian Open champion will begin against Ukraine's Lesia Tsurenko
Rafael Nadal left German qualifier Yannick Maden no hope as he booked his ticket for the third round of the French Open in ruthless fashion with a 6-1, 6-2, 6-4 victory.
Thousands of mask-free spectators flocked into the stadium
Ferrer, 37, announced earlier in the year he would end his 19-year career at the Madrid Open and prolonged his time on court by a day by beating Roberto Bautista Agut on Tuesday, but was easily overpowered by world number four Zverev.
A summary of Thursday's play at the US Open.
Images from Day 2 of the Australian Open in Melbourne on Tuesday